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252010 Debromohymenialdisine, Stylotella aurantium

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DBH

252010
  
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      Overview

      Description
      OverviewAn alkaloid isolated from a shallow-water marine sponge that acts as a highly selective inhibitor of G2 phase DNA damage checkpoint (IC50 = 8 µM). Exhibits moderate cytotoxicity (IC50 = 25 µM) toward MCF-7 cells. Acts by blocking the activities of checkpoint kinases Chk1 (IC50 = 3 µM) and Chk2 (IC50 = 3.5 µM). Inhibition is competitive with respect to ATP and does not affect the activities of other kinases.
      Catalogue Number252010
      Brand Family Calbiochem®
      SynonymsDBH
      References
      ReferencesCurman, D., et al. 2001. J. Biol. Chem. 276, 17914.
      Product Information
      CAS number125118-55-0
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₁H₁₁N₅O₂
      Chemical formulaC₁₁H₁₁N₅O₂
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetG2 phase DNA damage checkpoint
      Primary Target IC<sub>50</sub>8 µM
      Secondary targetChk1 (IC₅₀ = 3 µM) and Chk2 (IC₅₀ = 3.5 µM), cytotoxicity (IC₅₀ = 25 µM) toward MCF-7 cells
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      252010 0