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251650 Damnacanthal - CAS 477-84-9 - Calbiochem

A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase.

Damnacanthal - CAS 477-84-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde

Primary Target: p56lck autophosphorylation
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251650
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Overview

Key Spec Table

CAS #Empirical Formula
477-84-9C₁₆H₁₀O₅

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251650-1MG
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      Description
      OverviewA cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
      Catalogue Number251650
      Brand Family Calbiochem®
      Synonyms3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
      References
      ReferencesFaltynek, C.R., et al. 1995. Biochemistry 34, 12404.
      Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
      Koumaglo, K., et al. 1992. Planta Med. 58, 533.
      Product Information
      CAS number477-84-9
      ATP CompetitiveN
      FormOrange-yellow solid
      Hill FormulaC₁₆H₁₀O₅
      Chemical formulaC₁₆H₁₀O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetp56lck autophosphorylation
      Primary Target IC<sub>50</sub>17 nM against p56lck autophosphorylation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      251650-1MG 04055977198553