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239835 Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem

Cyclosporin A, CAS 59865-13-3, is an immunosuppressant that induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. Induces cardiomyocytes formation from ESCs.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: NOS induced by interlukin-1-α
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      59865-13-3C₆₂H₁₁₁N₁₁O₁₂
      Description
      OverviewCyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells.
      Catalogue Number239835
      Brand Family Calbiochem®
      References
      ReferencesYan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press.
      Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7.
      Marumo, T., et al. 1995. Hypertension 25, 764.
      Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045.
      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
      Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877.
      Fast, D.J., et al. 1993. J. Interferon Res. 13, 235.
      Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
      Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.
      Product Information
      CAS number59865-13-3
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₆₂H₁₁₁N₁₁O₁₂
      Chemical formulaC₆₂H₁₁₁N₁₁O₁₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetNOS induced by interlukin-1-α
      Purity≥97% (dry basis)
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGZ4120000
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-24/25-36/37

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing and gloves.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      239835 0

      Documentation

      Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      239835

      References

      Reference overview
      Yan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press.
      Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7.
      Marumo, T., et al. 1995. Hypertension 25, 764.
      Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045.
      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
      Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877.
      Fast, D.J., et al. 1993. J. Interferon Res. 13, 235.
      Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
      Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.

      Brochure

      Title
      Protein Phosphatases Technical Bulletin

      Citations

      Title
    • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-January-2009 JSW
      DescriptionMaterial is a nonpolar cyclic oligopeptide with immunosuppressant activity. Appears to act via interaction with the intracellular protein cyclophilin. The cyclophilin-cyclosporin A complex is a potent inhibitor of the protein phosphatase activity of calcineurin (protein phosphatase 2B, PP2B). Induces apoptosis in rat thymocytes and in the murine B-cell lymphoma cell line, WEHI-231; however, it prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides, and TNFα. Induces cardiomyocytes from embryonic stem cells.
      FormWhite to off-white solid
      CAS number59865-13-3
      RTECSGZ4120000
      Chemical formulaC₆₂H₁₁₁N₁₁O₁₂
      Structure formulaStructure formula
      Purity≥97% (dry basis)
      SolubilityDMSO (25 mg/ml), Ethanol, Methanol, or chloroform
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 2752
      ReferencesYan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press.
      Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7.
      Marumo, T., et al. 1995. Hypertension 25, 764.
      Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045.
      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
      Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877.
      Fast, D.J., et al. 1993. J. Interferon Res. 13, 235.
      Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
      Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.
      Citation
    • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
      		•