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234610 Congo Red, High Purity - CAS 573-58-0 - Calbiochem

An amyloidophylic dye that specifically stains stacked β sheet aggregates.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

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234610
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
573-58-0C₃₂H₂₂N₆O₆S₂ · 2Na

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234610-500MG
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      Description
      OverviewAn amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
      Catalogue Number234610
      Brand Family Calbiochem®
      Synonyms3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na
      References
      ReferencesAltschuler, S.E., et al. 2012. Biochemistr in press.
      Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715.
      Fezoui, Y., et al. 2000. Amyloid 7, 166.
      Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095.
      Kramport, M., et al. 2000. Chem. Biol. 7, 855.
      Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673.
      Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484.
      Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768.
      Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.
      Product Information
      CAS number573-58-0
      ATP CompetitiveN
      FormRust crystalline solid
      Hill FormulaC₃₂H₂₂N₆O₆S₂ · 2Na
      Chemical formulaC₃₂H₂₂N₆O₆S₂ · 2Na
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAn amyloidophylic dye that specifically stains stacked β sheet aggregates
      Purity≥75% (dye content)
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQK1400000
      Safety Information
      S PhraseS: 25

      Avoid contact with eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      234610-500MG 04055977199635

      Documentation

      Congo Red, High Purity - CAS 573-58-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Congo Red, High Purity - CAS 573-58-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      234610

      References

      Reference overview
      Altschuler, S.E., et al. 2012. Biochemistr in press.
      Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715.
      Fezoui, Y., et al. 2000. Amyloid 7, 166.
      Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095.
      Kramport, M., et al. 2000. Chem. Biol. 7, 855.
      Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673.
      Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484.
      Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768.
      Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-September-2012 JSW
      Synonyms3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na
      DescriptionAn amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
      FormRust crystalline solid
      Recommended reaction conditionsDissolve 0.5 g Congo Red in 80 ml of absolute ethanol. To this solution add 20 ml of 10% NaCl solution (2 g/20 ml of water). Filter before use. Immerse coverslips containing cells or sections into this solution for 3 min at room temperature. Wash with several exchanges of distilled H2O until the water runs is clear. Dehydrate with ascending alcohol solutions (50%, 70%, 80%, 95% x 2, 100% x 2). Clear with 100% xylene. Mount coverslip onto slide using Permount or other suitable organic mounting medium and view under a microscope. Amyloid deposits will appear red to pink-red. With a polarizing microscope, amyloid deposits show an apple-green birefringence.
      CAS number573-58-0
      RTECSQK1400000
      Chemical formulaC₃₂H₂₂N₆O₆S₂ · 2Na
      Structure formulaStructure formula
      Purity≥75% (dye content)
      SolubilityEthanol or H₂O (10 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).
      Toxicity Standard Handling
      Merck USA index14, 2498
      ReferencesAltschuler, S.E., et al. 2012. Biochemistr in press.
      Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715.
      Fezoui, Y., et al. 2000. Amyloid 7, 166.
      Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095.
      Kramport, M., et al. 2000. Chem. Biol. 7, 855.
      Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673.
      Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484.
      Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768.
      Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.