Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
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Select A Species, Panel Type, Kit or Sample Type
To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
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96-Well Plate
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Add Additional Reagents (Buffer and Detection Kit is required for use with MAPmates)
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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Compound Generation
Drug discovery groups that once tested hundreds of novel chemical entities (NCEs) per screen now process thousands daily.More
Drug discovery groups that once tested hundreds of novel chemical entities (NCEs) per screen now process thousands daily. Less
C7735Drug discovery groups that once tested hundreds of novel chemical entities (NCEs) per screen now process thousands daily.
Drug discovery groups that once tested hundreds of novel chemical entities (NCEs) per screen now process thousands daily. This increase in throughput is due in large part to the advances in lead compound generation methods like combinatorial chemistry synthesis. Using this technique, researchers can rapidly produce large compound libraries, which are then screened for interactions with the disease target.
Bead Cleavage Protocol
1.
Place synthesis beads in suitable reaction vessel
2.
Add reactants; seal; react
3.
Transfer beads to MultiScreen filter plate; add cleavage chemicals; incubate
4.
Filter drug compound into receiver plate, leaving beads in MultiScreen plate
MultiScreen Solvinert Plates
All MultiScreen Solvinert plate materials are selected for broad chemical compatibility and enable extended in-plate incubations with no leaking. The one-piece plate designs incorporate rigid sidewalls to facilitate use with robotic gripper arms and provide space for barcode labels.
They are available with chemically-resistant hydrophilic and hydrophobic membranes to accommodate aqueous and non-aqueous samples. Both membranes are highly retentive (>99% retention of acid precipitated BSA).
For the broadest chemical resistance, hydrophobic PTFE membrane is recommended. Designed for extended sample incubation times and the lowest extractables, hydrophobic PTFE membrane is ideal for NCE cleavage and cleanup, as well as peptide synthesis. They are also suitable for sample recovery following in-plate compound cleavage from solids or beads.
Hydrophilic PTFE membrane is optimized for low drug and protein binding with excellent throughput in typical aqueous and solvent sample preparation. High sample recoveries and low extractables provide for optimum analysis by HPLC and LC-MS/MS.
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