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219557 Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: sterol & fatty acid biosynthesis
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219557
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
17397-89-6C₁₂H₁₇NO₃

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219557-5MG
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      Description
      OverviewAn antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.
      Catalogue Number219557
      Brand Family Calbiochem®
      References
      ReferencesLoftus, T.M., et al. 2000. Science 288, 2379.
      Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
      Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
      Product Information
      CAS number17397-89-6
      FormWhite to off-white solid
      Hill FormulaC₁₂H₁₇NO₃
      Chemical formulaC₁₂H₁₇NO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetsterol & fatty acid biosynthesis
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSJR1670000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219557-5MG 04055977218138

      Documentation

      Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      219557

      References

      Reference overview
      Loftus, T.M., et al. 2000. Science 288, 2379.
      Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
      Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      DescriptionAn anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number17397-89-6
      RTECSJR1670000
      Chemical formulaC₁₂H₁₇NO₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (10 mg/ml), Ethanol (5 mg/ml) or Acetone
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 2004
      ReferencesLoftus, T.M., et al. 2000. Science 288, 2379.
      Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
      Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.