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219419 Cathepsin Inhibitor III - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₂₇H₂₇N₃O₇

Pricing & Availability

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219419-1MG
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      Description
      OverviewCysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 1 x 104 M-1 sec-1), cathepsin L (k2/Ki = 1.5 x 105 M-1 sec-1), cathepsin S (k2/Ki = 6.6 x 104 M-1 sec-1), and papain (k2/Ki = 1 x 103 M-1 sec-1).
      Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
      Catalogue Number219419
      Brand Family Calbiochem®
      SynonymsZ-FG-NHO-BzOME
      References
      ReferencesDemuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
      Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₇H₂₇N₃O₇
      Chemical formulaC₂₇H₂₇N₃O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcathepsin B
      Primary Target K<sub>i</sub>k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹
      Purity>90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Phe-Gly-NHO-Bz-pOMe
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      219419-1MG 04055977218336