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218765 Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem

A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-LEHD-AFC

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218765
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Overview

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218765-1MG
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      218765-5MG
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          Description
          OverviewA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). May also act as a substrate for caspase-4 and caspase-5. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
          Catalogue Number218765
          Brand Family Calbiochem®
          SynonymsAc-LEHD-AFC
          References
          ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
          Product Information
          CAS number210345-03-2
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₃₃H₃₈F₃N₇O₁₁
          Chemical formulaC₃₃H₃₈F₃N₇O₁₁
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetA fluorogenic substrate for caspase-9
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Emission max.
          Excitation max.
          Peptide SequenceAc-Leu-Glu-His-Asp-AFC
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          218765-1MG 07790788060237
          218765-5MG 04055977218671

          Documentation

          Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          218765

          References

          Reference overview
          Ito, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-June-2008 RFH
          SynonymsAc-LEHD-AFC
          DescriptionA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          CAS number210345-03-2
          Chemical formulaC₃₃H₃₈F₃N₇O₁₁
          Peptide SequenceAc-Leu-Glu-His-Asp-AFC
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from moisture
          Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.