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218696 Casein Kinase I Inhibitor, D4476 - CAS 301836-43-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
301836-43-1C₂₃H₁₈N₄O₃

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      Description
      OverviewA cell-permeable triaryl substituted imidazolo compound that acts as a potent, reversible and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 0.2 µM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 0.5 µM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and only weakly affects the activities of a panel of kinases tested, including PKB, SGK and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1a in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
      Catalogue Number218696
      Brand Family Calbiochem®
      SynonymsCK1 Inhibitor, 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
      References
      ReferencesRena, G., et al. 2004. EMBO Reports 5, 60.
      Product Information
      CAS number301836-43-1
      ATP CompetitiveY
      FormCrystalline solid
      Hill FormulaC₂₃H₁₈N₄O₃
      Chemical formulaC₂₃H₁₈N₄O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCK1, CK1d
      Primary Target IC<sub>50</sub>0.2 µM against CK1 from S. pombe; 0.3 µM for CK1δ 0.5 µM against ALK5
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      218696-1MG 04055977202496