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208851 Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC₅₀ = 0.5-1 nM) and protein phosphatase 1 (PP1; IC₅₀ = 2 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PP2A
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208851
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
101932-71-2C₅₀H₈₁N₄O₁₅P

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208851-10UG
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      		 Glass bottle 10 μg
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      Description
      OverviewA cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC50 = 0.5-1 nM) and protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent γ-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674. Also available as a 100 µM solution in DMSO (Cat. No. 508226).
      Catalogue Number208851
      Brand Family Calbiochem®
      References
      ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
      Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
      Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
      Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
      Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
      Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
      Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
      Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
      Product Information
      CAS number101932-71-2
      ATP CompetitiveN
      FormClear film to white crystalline powder
      Hill FormulaC₅₀H₈₁N₄O₁₅P
      Chemical formulaC₅₀H₈₁N₄O₁₅P
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPP2A
      Primary Target IC<sub>50</sub>0.5-1 nM and 2 nM against protein phosphatase 2A (PP2A) and protein phosphatase 1 (PP1)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25-38

      Toxic by inhalation, in contact with skin and if swallowed.
      Irritating to skin.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      208851-10UG 04055977219470

      Documentation

      Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      208851

      References

      Reference overview
      Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
      Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
      Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
      Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
      Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
      Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
      Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
      Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

      Brochure

      Title
      Protein Phosphatases Technical Bulletin

      Citations

      Title
    • Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-June-2011 JSW
      DescriptionCell-permeable protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca2+-activated K+ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
      FormClear film to white crystalline powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number101932-71-2
      Chemical formulaC₅₀H₈₁N₄O₁₅P
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO or Ethanol (2 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.
      Toxicity Toxic
      ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
      Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
      Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
      Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
      Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
      Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
      Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
      Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
      Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
      Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
      Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
      Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
      Citation
    • Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.
      		•