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420358 CBFβ Activator, Kartogenin - CAS 4727-31-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
4727-31-5C₂₀H₁₅NO₃

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420358-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFβ leading to nuclear localization of CBFβ and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breakdown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs.
      Catalogue Number420358
      Brand Family Calbiochem®
      Synonyms2-(Biphenyl-4-ylcarbamoyl)benzoic acid
      References
      ReferencesJohnson, K., et al. 2012. Science 336, 717.
      Product Information
      CAS number4727-31-5
      FormWhite solid
      Hill FormulaC₂₀H₁₅NO₃
      Chemical formulaC₂₀H₁₅NO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      420358-25MG 04055977187540