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531000 Brk Inhibitor, Cpd 4f - Calbiochem

A cell permeable, highly potent, and very selective inhibitor of breast tumor kinase (Brk; IC₅₀ = 3.15 nM). Displays anti-proliferative activity against multiple breast cancer cell lines.

Brk Inhibitor, Cpd 4f - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PTK6 Inhibitor, Breast Tumor Kinase Inhibitor

Primary Target: Brk
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531000
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₁₃N₃O

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      Description
      OverviewA cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531000
      Brand Family Calbiochem®
      SynonymsPTK6 Inhibitor, Breast Tumor Kinase Inhibitor
      References
      ReferencesMahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.
      Product Information
      FormLight beige powder
      Hill FormulaC₁₇H₁₃N₃O
      Chemical formulaC₁₇H₁₃N₃O
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBrk
      Primary Target IC<sub>50</sub>3.15 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.31000.0001 04055977242485

      Documentation

      Brk Inhibitor, Cpd 4f - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Mahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-September-2014 JSW
      SynonymsPTK6 Inhibitor, Breast Tumor Kinase Inhibitor
      DescriptionA cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).
      FormLight beige powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₃N₃O
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
      Toxicity Standard Handling
      ReferencesMahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.