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203732 Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem

Lipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Brevetoxin B, GbTx-2

Primary Target: Neurotoxin that binds to Na+ channels on nerves and muscles.
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203732
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
79580-28-2C₅₀H₇₀O₁₄

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203732-100UG
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      		 Glass bottle 100 μg
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      Description
      OverviewLipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes. Binds at site 5 on the voltage-sensitive Na+ channel.
      Catalogue Number203732
      Brand Family Calbiochem®
      SynonymsBrevetoxin B, GbTx-2
      References
      ReferencesEdwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
      Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
      Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
      Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
      Baden, G. 1989. FASEB J. 3, 1807.
      Baden, D.G., et al. 1988. Toxicon 26, 97.
      Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
      Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
      Nakanishi, K. 1985. Toxicon 23, 473.
      Baden, D.G., et al. 1982. Toxicon 19, 455.
      Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
      Product Information
      CAS number79580-28-2
      ATP CompetitiveN
      FormTan to white solid
      Hill FormulaC₅₀H₇₀O₁₄
      Chemical formulaC₅₀H₇₀O₁₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNeurotoxin that binds to Na+ channels on nerves and muscles.
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXW5886000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.


      From Catalog:
      Solubitlity- removed acetone, EtOAc
      End use certificateY
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203732-100UG 04055977203851

      Documentation

      Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      203732

      References

      Reference overview
      Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
      Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
      Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
      Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
      Baden, G. 1989. FASEB J. 3, 1807.
      Baden, D.G., et al. 1988. Toxicon 26, 97.
      Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
      Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
      Nakanishi, K. 1985. Toxicon 23, 473.
      Baden, D.G., et al. 1982. Toxicon 19, 455.
      Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-May-2008 RFH
      SynonymsBrevetoxin B, GbTx-2
      DescriptionLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na+ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.
      FormTan to white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number79580-28-2
      RTECSXW5886000
      Chemical formulaC₅₀H₇₀O₁₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityEthyl acetate, Methanol or H₂O
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.


      From Catalog:
      Solubitlity- removed acetone, EtOAc
      Toxicity Highly Toxic
      ReferencesEdwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
      Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
      Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
      Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
      Baden, G. 1989. FASEB J. 3, 1807.
      Baden, D.G., et al. 1988. Toxicon 26, 97.
      Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
      Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
      Nakanishi, K. 1985. Toxicon 23, 473.
      Baden, D.G., et al. 1982. Toxicon 19, 455.
      Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Openers