203830 Sigma-AldrichBRD2 Inhibitor II, BIC1 - CAS 433249-32-2 - Calbiochem
The BRD2 Inhibitor II, BIC1 controls the biological activity of BRD2.
More>> The BRD2 Inhibitor II, BIC1 controls the biological activity of BRD2. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 1-(2-(1H-Benzimidazol-2-ylsulfanyl)ethyl)-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione, 1-(2-(1H-Benzo[d]imidazol-2-ylthio)ethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione, BRD2 Bromodomain-Interactive Compound, BIC1
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 433249-32-2 | C₁₇H₁₆N₄S₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 203830-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable benzimidazolyl-benzimidazolothione that targets the BD1 domain of the BET family member BRD2 (Kd = 28 µM), making it inaccessible for acetylated H4K12 (histone H4 Lys12) binding. Shown to effectively inhibit TSA- (Cat. No. 647925; 1 h 1 µM) induced BRD2 BD1-H4K12 association in COS7 cells (100% inhibition by 60 µM BIC1) and greatly suppress active Ras-induced SV40 promoter transcription activity in HeLa cells (70% inhibition by 5 µM BIC1), while being much less effective against BRDT BD1 binding to acetylated H4K5/K8. |
| Catalogue Number | 203830 |
| Brand Family | Calbiochem® |
| Synonyms | 1-(2-(1H-Benzimidazol-2-ylsulfanyl)ethyl)-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione, 1-(2-(1H-Benzo[d]imidazol-2-ylthio)ethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione, BRD2 Bromodomain-Interactive Compound, BIC1 |
| References | |
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| References | Ito, T., et al. 2011. Chem. Biol. 18, 495. |
| Product Information | |
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| CAS number | 433249-32-2 |
| Form | Off-white solid |
| Hill Formula | C₁₇H₁₆N₄S₂ |
| Chemical formula | C₁₇H₁₆N₄S₂ |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 203830-10MG | 04055977204049 |
Documentation
BRD2 Inhibitor II, BIC1 - CAS 433249-32-2 - Calbiochem SDS
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BRD2 Inhibitor II, BIC1 - CAS 433249-32-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 203830 |
References
| Reference overview |
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| Ito, T., et al. 2011. Chem. Biol. 18, 495. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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