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203704 BPIQ-II

A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 8 pM).

BPIQ-II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]-quinazoline

Primary Target: EGFR
203704
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      171179-32-1C₁₅H₁₀BrN₅
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). Blocks EGF-mediated mitogenesis in Swiss/3T3 cells (IC50 = 46 nM).
      Catalogue Number203704
      Brand Family Calbiochem®
      Synonyms8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]-quinazoline
      References
      ReferencesRewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
      Product Information
      CAS number171179-32-1
      FormPale pink solid
      Hill FormulaC₁₅H₁₀BrN₅
      Chemical formulaC₁₅H₁₀BrN₅
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>8 pM
      Secondary targetgrowth factor mediated mitogenisis in swiss 3T3 cells (Ki = 46 nM)
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203704 0

      Documentation

      BPIQ-II Certificates of Analysis

      TitleLot Number
      203704

      References

      Reference overview
      Rewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]-quinazoline
      DescriptionA cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.008 nM). Blocks growth factor mediated mitogenesis in Swiss 3T3 cells (IC50 = 46 nM).
      FormPale pink solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number171179-32-1
      Chemical formulaC₁₅H₁₀BrN₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.