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616399 Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Kallikrein Inactivator

Primary Target: chymotrypsin
616399
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #
      9087-70-1
      Description
      Overview

      This product has been discontinued.



      Competitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.
      Note: 1 KU = 1000 K.I.U.
      Catalogue Number616399
      Brand Family Calbiochem®
      SynonymsKallikrein Inactivator
      References
      ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
      Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
      Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
      Product Information
      CAS number9087-70-1
      Activity≥6500 KIU/ml
      Unit of DefinitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
      ATP CompetitiveN
      FormLiquid
      FormulationIn isotonic NaCl, aseptically filled.
      PI10.5
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetchymotrypsin
      Primary Target IC<sub>50</sub>Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYN5080000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      616399 0

      Documentation

      Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      616399

      References

      Reference overview
      Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
      Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
      Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2010 JSW
      SynonymsKallikrein Inactivator
      DescriptionCompetitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.
      FormLiquid
      FormulationIn isotonic NaCl, aseptically filled.
      CAS number9087-70-1
      RTECSYN5080000
      Activity≥6500 KIU/ml
      Unit definitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Toxicity Standard Handling
      Merck USA index14, 757
      ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
      Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
      Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.