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07-1829 Anti-phospho-NF-kB (p100) (Ser707) Antibody

Use Anti-phospho-NF-kB (p100) (Ser707) Antibody (Rabbit Polyclonal Antibody) validated in WB, PIA, DB to detect phospho-NF-kB (p100) (Ser707) also known as Nuclear factor NF-kappa-B p100 subunit or H2

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Anti-phospho-NF-kB (p100) (Ser707) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: NFKB2, LYT10 UniProt Number: Q00653
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07-1829
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, PIA, DBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1829
      DescriptionAnti-phospho-NF-kB (p100) (Ser707) Antibody
      Alternate Names
      • Nuclear factor NF-kappa-B p100 subunit
      • DNA-binding factor KBF2
      • H2TF1
      • Lymphocyte translocation chromosome 10 protein
      • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
      • Oncogene Lyt-10
      • Lyt10
      • Nuclear factor NF-kappa-B p52 subunit
      Background InformationNF-kappa-B (NF-kB) is a family of ubiquitous transcription factors, which includes RelA, RelB, NF-kB1 and NF-kB2. The NF-kB family regulates multiple cellular processes, including cell growth, differentiation, inflammation, immunity, and apoptosis. In general, inactive forms of NF-kB proteins, bound by IkappaB inhibitory proteins, are present in the cytoplasm, whereas activated forms translocate to the nucleus where they exert transcriptional activity. The p100 subunit is an inactive precursor of NF-kB2, and is proteolyzed to generate the functional p52 protein and enable the formation of an active NF-kB2/p52 dimeric complex. The processing of p100 to form p52 is induced by the NF-kappaB-inducing kinase (NIK), which recruits IkappaB kinase alpha to p100, resulting in phosphorylating of p100 at serines 99, 108, 115, 123, and 872, which is required for subsequent ubiquitination and processing of p100 by the beta-TrCP ubiquitin ligase. Nuclear p100 is phosphorylated at serine 707 by GSK3, which promotes its degradation by Fbxw7α.
      Product Information
      FormatAffinity Purified
      Control
      • Phosphorylated and non-phosphorylated NF-kB peptides
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-phospho-NF-kB (p100) (Ser707) Antibody (Rabbit Polyclonal Antibody) validated in WB, PIA, DB to detect phospho-NF-kB (p100) (Ser707) also known as Nuclear factor NF-kappa-B p100 subunit or H2TF1.
      Key Applications
      • Western Blotting
      • Peptide Inhibition Assay
      • Dot Blot
      Application NotesPeptide Inhibition Analysis: A 1:500 dilution from a representative lot blocked phospho-NF-kB (p100) (Ser707) in non-starved HEK293 cell lysates.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human NF-kB (p100) phosphorylated at Ser707.
      EpitopePhosphorylated Ser707
      HostRabbit
      SpecificityThis antibody recognizes NF-kB (p100) phosphorylated at Ser707.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NFKB2
      • LYT10
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~120 kDa observed
      Product Usage Statements
      Quality AssuranceDot Blot Specificity Analysis: Phosphorylated and non-phosphorylated NF-kB peptides (see Table) were probed with Anti-phospho-NF-kB (p100) (Ser707) (1:500 dilution).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Global Trade Item Number
      Catalogue Number GTIN
      07-1829 04053252694646