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MAB375-C Anti-Tau Antibody, clone Tau-2 (Ascites Free)

Anti-Tau Antibody, clone Tau-2 (Ascites Free) is an antibody against Tau for use in Immunohistochemistry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: MAPT, TAU UniProt Number: P29172
MAB375-C
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB375-C
      ReplacesMAB375
      DescriptionAnti-Tau Antibody, clone Tau-2 (Ascites Free)
      Alternate Names
      • Microtubule-associated protein tau
      • Neurofibrillary tangle protein
      • Paired helical filament-tau
      • PHF-tau
      • Tau
      Background InformationMicrotubule-associated protein tau (UniProt P29172; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU) gene (Gene ID 281296) in bovine species. Extracellular plaque deposits composed of amyloid-β and intracellular neurofibrillary tangles (NFTs) composed of truncated and hyperphosphorylated tau are two neuropathological hallmarks of Alzheimer's disease (AD). Tau pathology (tauopathy) can cause toxicity when the brain is devoid of amyloid plaques, and tangle pathology correlates better with clinical dementia than amyloid pathology. Abnormal processing of tau by hyperphosphorylation and proteolytic truncation contribute to the toxicity of tau. Tau is known to be cleaved by various proteases, including caspases, calpains, cathepsins, thrombin, and puromycin-sensitive aminopeptidase, as well as the lysosomal cysteine proteinase asparagine endopeptidase (AEP). MAPK, GSK-3, and Cdk-5 are three known kinases that target various tau phosphorylation sites. Tau also undergoes other types of posttranslational modifications, including glycosylation, ubiquitination, glycation, polyamination, nitration, and lysine methylation, which are believed to be important for its non-pathological functions, including polymerization and stabilization of microtubules.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Tau Antibody, clone Tau-2 (Ascites Free) is an antibody against Tau for use in Immunohistochemistry.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:5,000 dilution from a representative lot detected Tau in rat kidney tissue.
      Biological Information
      ImmunogenBovine Tau.
      CloneTau-2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityTau from bovine, feline and abnormal human tau in Alzheimer's disease.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat. Predicted to react with Bovine, Feline based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MAPT
      • TAU
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight46 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in Alzheimer's diseased human cerebral cortex tissue.

      Immunohistochemistry Analysis: A 1:5,000 dilution of this antibody detected Tau-positive plaques in Alzheimer's diseased human cerebral cortex tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB375-C 04055977294873

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies