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574660 Anti-Survivin Rabbit pAb

This Anti-Survivin Rabbit pAb is validated for use in ELISA, Immunoblotting, Immunofluorescence, Immunohistochemistry for the detection of Survivin.

Anti-Survivin Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Inhibitor of Apoptosis Protein, Anti-TIAP

574660
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      OverviewRecognizes the ~16.5 kDa survivin protein. Does not cross-react with EPR-1.
    • Antibody Target Gene Symbol: BIRC5
    • Target Synonym: AAC-11, AP14, API4, EPR-1, SURVIVIN, SURVIVIN 2B, Survivin delta ex3, survivin40, TIAP
    • Entrez Gene Name: baculoviral IAP repeat-containing 5
    • Hu Entrez ID: 332 (Related Antibodies: PC527)
    • Mu Entrez ID: 11799
    • Rat Entrez ID: 64041

      • This product has been discontinued.
      Catalogue Number574660
      Brand Family Calbiochem®
      SynonymsAnti-Inhibitor of Apoptosis Protein, Anti-TIAP
      References
      ReferencesAdida, C., et al. 1998. Am. J. Pathol.152, 43.
      Li, F., et al. 1998. Nature 396, 580.
      Lu, C.-D., et al. 1998. Cancer Res. 58, 1808.
      Ambrosini, G., et al. 1997. Nature Med. 3, 917.
      Product Information
      FormLiquid
      FormulationIn PBS, 0.1% BSA.
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunoblotting (Western Blotting)
      Immunofluorescence
      Immunohistochemistry
      Application NotesELISA (1:10,000-1:100,000)
      Immunoblotting (1-10 µg/ml, chemiluminescence)
      Immunofluorescence (2-20 µg/ml)
      Immunohistochemistry (2-20 µg/ml)
      Application CommentsDoes not cross-react with EPR-1. Variables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids near the C-terminus of human survivin
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Do not re-freeze aliquots.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      574660 0

      Documentation

      Anti-Survivin Rabbit pAb Certificates of Analysis

      TitleLot Number
      574660

      References

      Reference overview
      Adida, C., et al. 1998. Am. J. Pathol.152, 43.
      Li, F., et al. 1998. Nature 396, 580.
      Lu, C.-D., et al. 1998. Cancer Res. 58, 1808.
      Ambrosini, G., et al. 1997. Nature Med. 3, 917.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-August-2007 RFH
      SynonymsAnti-Inhibitor of Apoptosis Protein, Anti-TIAP
      ApplicationELISA (1:10,000-1:100,000)
      Immunoblotting (1-10 µg/ml, chemiluminescence)
      Immunofluorescence (2-20 µg/ml)
      Immunohistochemistry (2-20 µg/ml)
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~16 kDa survivin protein.
      BackgroundSurvivin is a member of the inhibitors of apoptosis proteins (IAPs), a widely expressed family of proteins that suppress apoptosis through direct caspase and pro-caspase inhibition. Similar to oncofetal antigens, survivin is highly expressed in less-differentiated embryonic cells or rapidly dividing tumor cells but not in fully differentiated adult tissues. Elevated levels of survivin are found in human fetal lung, liver, heart, kidney, and gastrointestinal tract and in most mouse embryonic tissues. High levels of survivin expression are also found in many common human cancers, including cancers of the lung, colon, pancreas, prostate, and breast. Expression of survivin correlates with the presence of both p53 and Bcl-2.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids near the C-terminus of human survivin
      IsotypeIgG
      Specieshuman, mouse
      FormLiquid
      FormulationIn PBS, 0.1% BSA.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsDoes not cross-react with EPR-1. Variables associated with assay conditions will dictate the optimal working dilution.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Do not re-freeze aliquots.
      Toxicity Standard Handling
      ReferencesAdida, C., et al. 1998. Am. J. Pathol.152, 43.
      Li, F., et al. 1998. Nature 396, 580.
      Lu, C.-D., et al. 1998. Cancer Res. 58, 1808.
      Ambrosini, G., et al. 1997. Nature Med. 3, 917.