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MABN838 Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1

This Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Retinal Dehydrogenase 1/ALDH1A1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Signaling Neuroscience Gene Symbol: ALDH1A1, ALDC, ALDH1, PUMB1 UniProt Number: P00352
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MABN838
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN838
      DescriptionAnti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1
      Alternate Names
      • Retinal Dehydrogenase 1
      • RALDH 1
      • RalDH1
      • ALDH-E1
      • ALHDII
      • Aldehyde dehydrogenase family 1 member A1
      • Aldehyde dehydrogenase, cytosolic
      Background InformationRetinal dehydrogenase 1 (EC 1.2.1.36; UniProt P00352; also known as Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, ALDH-E1, ALHDII, RALDH 1, RalDH1) is encoded by the ALDH1A1 (also known as ALDC, ALDH1, PUMB1) gene (Gene ID 216) in human. ALDH1A1, ALDH1A2, and ALDH1A3 constitute the ALDH1A subfamily of aldehyde dehydrogenases that catalyze the oxidation of all-trans retinal and 9-cis retinal to all-trans retinoic acid and 9-cis retinoic acid, respectively. In addition to its role in detoxifing 4-hydroxy-2-nonenal (4-HNE) in the lens and cornea, ALDH1A1 is also involved in many other biological processes, including stem cell maintenance, UV-radiation resistance, melanogenesis, and spermatogenesis, by catalyzing the conversion of specific aldehydes to their corresponding carboxylic acids.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1k antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 8D7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of Retinal Dehydrogenase 1/ALDH1A1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in 10 µg of human cerebellum tissue lysate.
      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in human testis tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.
      EpitopeN-terminal
      Clone8D7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ALDH1A1
      • ALDC
      • ALDH1
      • PUMB1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~55 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Retinal Dehydrogenase 1/ALDH1A1 in 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN838 04055977288384

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies