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528215 Anti-PAI-1 Mouse mAb (MA-33B8)

Overview

Key Spec Table

Species ReactivityHostAntibody Type
H, RbMMonoclonal Antibody

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528215-100UG
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      Description
      OverviewRecognizes the ~50 kDa PAI-1 protein.
      Catalogue Number528215
      Brand Family Calbiochem®
      SynonymsAnti-Plasminogen Activator Inihibitor-1
      References
      ReferencesMontes, R., et al. 2000. Thromb. Haemost. 84, 65.
      Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
      Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
      Product Information
      FormLiquid
      FormulationIn 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Application ReferencesNeutralization Studies Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
      Key Applications Immunoblotting (Western Blotting)
      Neutralization Studies
      Application NotesImmunoblotting (10 µg/ml)
      Neutralization Studies (see application references)
      Application CommentsRapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      Immunogenhuman tPA-PAI-1 complex
      ImmunogenHuman
      CloneMA-33B8
      HostMouse
      Purity≥ 90% by SDS-PAGE
      IsotypeIgG
      Species Reactivity
      • Human
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Global Trade Item Number
      Catalogue Number GTIN
      528215-100UG 04055977196511