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MAB2076Z Anti-Integrin β6 Antibody, clone CSβ6, azide free

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MAB2076Z
100 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Mk, R, RbFC, IP, ICC, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2076Z
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin β6 Antibody, clone CSβ6, azide free
      Alternate Names
      • MAB2076
      Product Information
      FormatPurified
      PresentationSterile-filtered liquid at 1 mg/mL in PBS, containing no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin β6 Antibody, clone CSβ6, azide free detects level of Integrin β6 & has been published & validated for use in FC, IP, IC, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry (acetone fixation): Effective for Rabbit, rat, monkey, and human. Not effective for mouse tissue.

      Immunocytochemistry: Effective for F6, HT-29, H441 cell lines (others not tested).

      Flow cytometry: Effective for all species tested, including rabbit, rat, monkey, human, and mouse.

      Immunoprecipitation

      Optimal working dilutions must be determined by end user.
      Biological Information
      Immunogenbeta 6 knockout mice have been immunized with recombinant secreted human alpaVbeta6.
      CloneCSbeta6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityMonoclonal antibody MAB2076Z, raised by immunizing beta6 knockout mice with recombinant secreted human alphavbeta6, is useful for flow cytometry and immunoprecipitation in all species tested, including mouse. It also works well for immunohistochemistry of acetone-fixed tissues in several species, including rat, rabbit, monkey, and human. The antibody does not work well for immunohistochemistry of mouse tissue. This antibody does not recognize the aV subunit and does not react with alphaV integrins other than alphavbeta6. Because the antibody is not effective in western blot, it is unknown whether the epitope recognized by the antibody localizes to the alphavbeta6 heterodimer or to the beta6 subunit only.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Monkey
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGB6
      Non-Reactive Species
      • Mouse
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P18564 # Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands.
      SIZE: 788 amino acids; 85936 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P18564 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MAB2076Z 04053252504341