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MABN355 Anti-HAND2 Antibody, Clone 7D4.1

Detect HAND2 using this Anti-HAND2 Antibody, Clone 7D4.1 validated for use in western blotting & IHC.

Anti-HAND2 Antibody, Clone 7D4.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: HAND2, BHLHA26, DHAND UniProt Number: P61296
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MABN355
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN355
      DescriptionAnti-HAND2 Antibody, Clone 7D4.1
      Alternate Names
      • Heart- and neural crest derivatives-expressed protein 2
      • Class A basic helix-loop-helix protein 26
      • bHLHa26
      • Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
      • dHAND
      Background InformationHeart-and neural crest derivatives-expressed protein 2 , also known as Class A basic helix-loop-helix protein 26 (bHLHa26), or Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), and encoded by the gene HAND2/BHLHA26/DHAND, is a transcription factor that is essential for cardiac morphogenesis, particularly the formation of the right ventricle and the aortic arch arteries. Heart-and neural crest derivatives-expressed protein 2 is required for vascular development, angiogenesis and for limb development acting upstream of sonic hedgehog in the induction of the limb bud. Additionally, Heart-and neural crest derivatives-expressed protein 2 is central to cardiac neural crest cell development and involved in outflow tract morphogenesis as well as the maintenance of the adult heart and in the negative regulation of cardiac muscle cell apoptosis. Heart-and neural crest derivatives-expressed protein 2 is localized to the nucleus. Heart-and neural crest derivatives-expressed protein 2 is expressed in developing heart, lung and vascular system.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect HAND2 using this Anti-HAND2 Antibody, Clone 7D4.1 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected HAND2 in human placenta tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to the C-terminus outside the bHLH domain of human HAND2.
      EpitopeC-terminus outside the bHLH domain
      Clone7D4.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HAND2
      • BHLHA26
      • DHAND
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~30 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse heart tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected HAND2 in 10 µg of mouse heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN355 04053252946042