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07-551-25UG Anti-G9a (rabbit polyclonal IgG)

Use Anti-G9a Antibody (Rabbit Polyclonal Antibody) validated in WB to detect G9a also known as KMT1C.

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07-551-25UG
25 μg  
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      Description
      Catalogue Number07-551-25UG
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-G9a (rabbit polyclonal IgG)
      Alternate Names
      • KMT1C
      Background InformationProtein G9a (also known as Histone H3-K9 methyltransferase 3, Euchromatic histone-lysine N-methyltransferase 2 and HLA-B-associated transcript 8)
      References
      Product Information
      FormatPurified
      Control
      • Positive Control Included: HeLa Nuclear Extract (12-309).
      PresentationProtein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-G9a Antibody (Rabbit Polyclonal Antibody) validated in WB to detect G9a also known as KMT1C.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide (C-DERVDSDSKSEVEALTEQ) corresponding to amino acids 71-88 of human G9a.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityRecognizes human G9a protein.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryA cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.
      Gene Symbol
      • EHMT2
      • NG36/G9a
      • NG36
      • G9A
      • Em:AF134726.3
      • C6orf30
      • BAT8
      • FLJ35547
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96KQ7 # Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1 (By similarity).
      SIZE: 1210 amino acids; 132370 Da
      SUBUNIT: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1.
      SUBCELLULAR LOCATION: Nucleus. Note=Associates with euchromatic regions. Does not associate with heterochromatin.
      TISSUE SPECIFICITY: Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.
      DOMAIN:SwissProt: Q96KQ7 The SET domain mediates interaction with WIZ.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. & Contains 7 ANK repeats. & Contains 1 post-SET domain. & Contains 1 pre-SET domain. & Contains 1 SET domain.
      Molecular Weight140 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot HeLa nuclear extract cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-551-25UG 04054839342509

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