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AB10080 Anti-CYP450 Antibody, clone 2E1

Anti-CYP450 Antibody, clone 2E1 is an antibody against CYP450 for use in WB.

Anti-CYP450 Antibody, clone 2E1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: CYP2E1, OTTHUMP00000046571, CYPIIE1, CYP2E, P450C2E, P450-J, CPE1 UniProt Number: P05181
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AB10080
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10080
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CYP450 Antibody, clone 2E1
      Alternate Names
      • cytochrome P450
      References
      Product Information
      FormatSerum
      PresentationRaw Rabbit Serum with 0.1% Sodium Azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-CYP450 Antibody, clone 2E1 is an antibody against CYP450 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant CYP450 2E1
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
      Gene Symbol
      • CYP2E1
      • OTTHUMP00000046571
      • CYPIIE1
      • CYP2E
      • P450C2E
      • P450-J
      • CPE1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05181 # Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
      SIZE: 493 amino acids; 56849 Da
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
      SIMILARITY: SwissProt: P05181 ## Belongs to the cytochrome P450 family.
      Molecular Weight57 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 2-8°C from date of shipment
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10080 04053252514838

      Documentation

      Anti-CYP450 Antibody, clone 2E1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CYP450 Antibody, clone 2E1 Certificates of Analysis

      TitleLot Number
      Anti-CYP450, clone 2E1 POLYCLONAL ANTIBODY Q2912990

      References

      Reference overviewPub Med ID
      Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity
      Viaggi, C, et al
      J Neural Transm Suppl, :173-6 (2006)  2006

      		17017526 17017526
      Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite
      Cannady, Ellen A, et al
      Toxicol Sci, 73:423-30 (2003)  2003

      		12700394 12700394

      Data Sheet

      Title
      RABBIT ANTI- CYP450 2E1 POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies