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176872 Angiotensin Converting Enzyme-2, His•Tag®, Human, Recombinant, NSO Cells

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176872
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176872-10UG
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      Description
      OverviewRecombinant, human ACE-2 ectodomain (amino acids 1-740) fused at the C-terminus to a His•Tag® sequence and expressed in NSO cells. Native ACE-2 is an integral membrane zinc metalloprotease that can be inhibited by EDTA. ACE-2 cleaves angiotensins I and II. Plays an important role in regulating cardiovascular and renal functions. By SDS-PAGE, the apparent molecular mass of the glycosylated protein is ~120 kDa under either reducing or non-reducing condition.
      Catalogue Number176872
      Brand Family Calbiochem®
      SynonymsACE Homolog, ACEH, ACE-2
      References
      ReferencesTikellis, C., et al. 2003. Hypertension 41, 390.
      Tipnis, S.R., et al. 2000. J. Biol. Chem. 275, 33238.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will cleave 1 nmol MCA-YVADAPK(DNP)-OH per min at 25°C, pH 7.5.
      FormLiquid
      Quality LevelMQ100
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥0.8 unit/µg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsEndotoxins: ≤1.0 EU/µg ACE-2
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Global Trade Item Number
      Catalogue Number GTIN
      176872-10UG 04055977222999