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116825 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 2ʹ-O-Monobutyryl-, Rp-Isomer, Sodium Salt

116825
  
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      152218-23-0C₁₄H₁₇N₅O₆PS · Na
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, metabolically-stable precursor of Rp-cAMPS (Cat. No. 116814) that acts as a competitive inhibitor of protein kinase A type I and II. During metabolic activation by esterases, the inhibitor and butyrate are released. Reported to inhibit glucose-induced proliferation of the pancreatic β-cell line, INS-1. More lipophilic and cell-permeable than Rp-cAMPS.
      Note: 5 µmol = 2.19 mg.
      Catalogue Number116825
      Brand Family Calbiochem®
      SynonymsRp-MB-cAMPS, Na, PKA Inhibitor X
      References
      ReferencesVischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.
      Product Information
      CAS number152218-23-0
      ATP CompetitiveY
      DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₄H₁₇N₅O₆PS · Na
      Chemical formulaC₁₄H₁₇N₅O₆PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetPKA1, PKA2
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      116825 0