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123850 AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem

The AKR1C1 Inhibitor, 5-PBSA, also referenced under CAS 4906-68-7, controls the biological activity of AKR1C1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA

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123850
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Overview

Key Spec Table

CAS #Empirical Formula
4906-68-7C₁₃H₉BrO₃

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123850-25MG
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      Description
      OverviewA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
      Catalogue Number123850
      Brand Family Calbiochem®
      SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
      References
      ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
      El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
      Product Information
      CAS number4906-68-7
      FormWhite solid
      Hill FormulaC₁₃H₉BrO₃
      Chemical formulaC₁₃H₉BrO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥94% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      123850-25MG 04055977206296