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108219 Tris(hydroxymethyl)aminomethane hydrochloride

Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
1082190003
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      Fibre case 3 x 0,750 kg
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      1082191003
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          Plastic bottle 1 kg
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          1082195000
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              Plastic bottle 5 kg
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              1082199010
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                  Plastic drum 10 kg
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                  1082199012
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                      Bucket, plastic 12 kg
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                      1082199050
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                          Plastic drum 50 kg
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                          Description
                          Catalogue Number108219
                          SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
                          DescriptionTris(hydroxymethyl)aminomethane hydrochloride
                          References
                          Product Information
                          CAS number1185-53-1
                          EC number214-684-5
                          Hill FormulaC₄H₁₁NO₃˙ ClH
                          Chemical formulaC₄H₁₁NO₃*ClH
                          Molar Mass157.60 g/mol
                          HS Code2922 19 99
                          Structure formula ImageStructure formula Image
                          Quality LevelMQ500
                          Applications
                          Biological Information
                          Physicochemical Information
                          Density1.28 g/cm3 (20.2 °C)
                          Melting Point150.7 °C
                          pH value4.2 (100 g/l, H₂O, 20 °C)
                          Vapor pressure<0.1 hPa (50 °C)
                          Solubility561 g/l soluble
                          Dimensions
                          Materials Information
                          Toxicological Information
                          Safety Information according to GHS
                          Storage class10 - 13 Other liquids and solids
                          WGKWGK 1 slightly hazardous to water
                          Disposal3
                          Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
                          Safety Information
                          Product Usage Statements
                          Storage and Shipping Information
                          StorageStore at +15°C to +25°C.
                          Packaging Information
                          Transport Information
                          Supplemental Information
                          Specifications
                          Appearancewhite to almost white, crystalline powder
                          Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
                          Identity (IR-spectrum)conforms
                          pH-value (0.5 mol/l, water)3.5 - 5.0
                          Melting point147 - 153 °C
                          UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
                          UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
                          UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
                          UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
                          UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
                          Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
                          Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
                          Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
                          Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
                          Other residual solvents (ICH Q3C)excluded by manufacturing process
                          Sulfated ash≤ 0.03
                          Loss on Drying (105°C)≤ 0.5
                          Endotoxins< 2.5
                          Total aerobic microbial count≤ 10²
                          Total yeast and mould count
                          ≤ 10²
                          Salmonella spp.
                          absent in 10 g
                          E.coli
                          absent in 1 g
                          Staphylococcus aureus
                          absent in 1 g
                          Pseudomonas aeruginosa
                          absent in 1 g
                          Candida albicans
                          absent in 1 g
                          Bile tolerante gram negative bacteria
                          absent in 1 g
                          DNases (Exo- and endonucleases)
                          not detected
                          Proteases
                          not detected
                          RNases
                          not detected
                          Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                          Total yeast and mould count
                          ≤ 10²
                          Salmonella spp.
                          absent in 10 g
                          E.coli
                          absent in 1 g
                          Staphylococcus aureus
                          absent in 1 g
                          Pseudomonas aeruginosa
                          absent in 1 g
                          Candida albicans
                          absent in 1 g
                          Bile tolerante gram negative bacteria
                          absent in 1 g
                          DNases (Exo- and endonucleases)
                          not detected
                          Proteases
                          not detected
                          RNases
                          not detected
                          Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                          Global Trade Item Number
                          Catalogue Number GTIN
                          1082190003 04027269296049
                          1082191003 04027269196462
                          1082195000 04022536532899
                          1082199010 04022536702742
                          1082199012 04027269285586
                          1082199050 04054839392443

                          Documentation

                          Material Qualification Dossier

                          TitleVersion
                          6.0

                          Quality Management Dossier (Open Access)

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                          Operational Excellence Dossier

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                          Required Licenses

                          Title
                          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

                          Tris(hydroxymethyl)aminomethane hydrochloride SDS

                          Title

                          Safety Data Sheet (SDS) 

                          Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

                          Product Number PackagingSpecificationLot Number
                          1082190003 Fibre casePDF Specification Document
                          1082191003 Plastic bottlePDF Specification Document
                          1082195000 Plastic bottlePDF Specification Document
                          1082199010 Plastic drumPDF Specification Document
                          1082199012 Bucket, plasticPDF Specification Document
                          1082199050 Plastic drumPDF Specification Document

                          Certificates

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                          User Guides

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                          Raw Materials for Biopharmaceutical Manufacturing