Millipore Sigma Vibrant Logo

PC57 Anti-MSH2 (Ab-3) Rabbit pAb

This Anti-MSH2 (Ab-3) Rabbit pAb is validated for use in Frozen Sections, Immunoblotting, Immunoprecipitation, Paraffin Sections for the detection of MSH2 (Ab-3).

Anti-MSH2 (Ab-3) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Mismatch Repair Protein 2

View Products on Sigmaaldrich.com
PC57
  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      H, MRbPolyclonal Antibody
      Description
      OverviewRecognizes the ~100 kDa MSH2 protein in HCT116 and SW480 cells and in colon tissue.
      Catalogue NumberPC57
      Brand Family Calbiochem®
      SynonymsAnti-Mismatch Repair Protein 2
      References
      ReferencesBronner, C.E., et al. 1994. Nature 368, 258.
      Papadopoulos, N., et al. Science 263, 1625.
      Peltomäki, P.T. 1994. Ann. Medicine 26, 215.
      Fishel, R., et al. 1993. Cell 75, 1027.
      Leach, F.S., et al. 1993. Cell 75, 1215.
      Lindbolm, A., et al. 1993. Nat. Genet. 5, 279.
      Product Information
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
      Positive controlHCT116 OR SW480 cells or colon tissue
      PreservativeNone
      Quality LevelMQ100
      Applications
      Application ReferencesParaffin Sections Wilson, T.M., et al. Cancer Research 55, 5146.
      Key Applications Frozen Sections
      Immunoblotting (Western Blotting)
      Immunoprecipitation
      Paraffin Sections
      Application NotesFrozen Sections (2 µg/ml)
      Immunoblotting (1 µg/ml, chemiluminescence)
      Immunoprecipitation (1 µg/sample)
      Paraffin Sections (see application references)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenfull length, recombinant, human MSH2
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°c).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC57 0

      Documentation

      Anti-MSH2 (Ab-3) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-MSH2 (Ab-3) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC57

      References

      Reference overview
      Bronner, C.E., et al. 1994. Nature 368, 258.
      Papadopoulos, N., et al. Science 263, 1625.
      Peltomäki, P.T. 1994. Ann. Medicine 26, 215.
      Fishel, R., et al. 1993. Cell 75, 1027.
      Leach, F.S., et al. 1993. Cell 75, 1215.
      Lindbolm, A., et al. 1993. Nat. Genet. 5, 279.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-October-2007 RFH
      SynonymsAnti-Mismatch Repair Protein 2
      ApplicationFrozen Sections (2 µg/ml)
      Immunoblotting (1 µg/ml, chemiluminescence)
      Immunoprecipitation (1 µg/sample)
      Paraffin Sections (see application references)
      DescriptionPurified rabbit polyclonal antibody. Recognizes the ~100 kDa MSH2 protein.
      BackgroundThe MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma, while germline MSH2 mutations are responsible for approximately 50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids.
      HostRabbit
      Immunogen speciesHuman
      Immunogenfull length, recombinant, human MSH2
      IsotypeIgG
      Specieshuman, mouse
      Positive controlHCT116 OR SW480 cells or colon tissue
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°c).
      Toxicity Standard Handling
      ReferencesBronner, C.E., et al. 1994. Nature 368, 258.
      Papadopoulos, N., et al. Science 263, 1625.
      Peltomäki, P.T. 1994. Ann. Medicine 26, 215.
      Fishel, R., et al. 1993. Cell 75, 1027.
      Leach, F.S., et al. 1993. Cell 75, 1215.
      Lindbolm, A., et al. 1993. Nat. Genet. 5, 279.
      Application referencesParaffin Sections Wilson, T.M., et al. Cancer Research 55, 5146.