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PC09 Anti-PTHLP (Ab-2) (34-53) Rabbit pAb

Anti-PTHLP (Ab-2) (34-53) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Parathyroid Hormone-Like Protein, Anti-Parathyroid Hormone-Related Protein, Anti-PTHrP, Anti-PTHLH

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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      HRbPolyclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes parathyroid hormone-like protein. Does not cross-react with human PTH.
      Catalogue NumberPC09
      Brand Family Calbiochem®
      SynonymsAnti-Parathyroid Hormone-Like Protein, Anti-Parathyroid Hormone-Related Protein, Anti-PTHrP, Anti-PTHLH
      References
      ReferencesThorikay, M., et al. 1989. Endocrinology 124, 111.
      Danks, J.A., et al. 1988. J. Bone Min. Res. 3, S214.
      Mangin, M., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 597.
      Burtis, W.J., et al. 1987. J. Biol. Chem. 262, 7151.
      Moseley, J.M., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 5048.
      Strewler, G.J., et al. 1987. J. Clin. Invest. 80, 1803.
      Suva, L.J., et al. 1987. Science 237, 893.
      Godsall, J.W., et al. 1986. Recent Progress Hormone Res. 42, 705.
      Product Information
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
      Positive controlAny renal carcinoma cell line or normal skin
      Preservative≤0.1% sodium azide
      Quality LevelMQ100
      Applications
      Key Applications Flow Cytometry
      Immunoblotting (Western Blotting)
      Immunofluorescence
      Immunoprecipitation
      Paraffin Sections
      Application NotesFlow Cytometry (1-5 µg/ml)
      Immunoblotting (1-5 µg/ml)
      Immunofluorescence (1-5 µg/ml)
      Immunoprecipitation (1-2 µg/sample)
      Paraffin Sections (1-10 µg/ml, neuraminidase pre-treatment required)
      Application CommentsRecognizes human PTHLP, but the homology between the human and rat genes suggests that the antibody may also recognize PTHLP from other species. The antibody shows no cross reactivity with human parathyroid hormone. The immunogen, PTHLP (Peptide-1) Cat. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide (AEIRATSEVSPNSKPSPNTK) corresponding to amino acids 34-53 of human PTHLP
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Yes
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC09 0

      Documentation

      Anti-PTHLP (Ab-2) (34-53) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PTHLP (Ab-2) (34-53) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC09

      References

      Reference overview
      Thorikay, M., et al. 1989. Endocrinology 124, 111.
      Danks, J.A., et al. 1988. J. Bone Min. Res. 3, S214.
      Mangin, M., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 597.
      Burtis, W.J., et al. 1987. J. Biol. Chem. 262, 7151.
      Moseley, J.M., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 5048.
      Strewler, G.J., et al. 1987. J. Clin. Invest. 80, 1803.
      Suva, L.J., et al. 1987. Science 237, 893.
      Godsall, J.W., et al. 1986. Recent Progress Hormone Res. 42, 705.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      SynonymsAnti-Parathyroid Hormone-Like Protein, Anti-Parathyroid Hormone-Related Protein, Anti-PTHrP, Anti-PTHLH
      ApplicationFlow Cytometry (1-5 µg/ml)
      Immunoblotting (1-5 µg/ml)
      Immunofluorescence (1-5 µg/ml)
      Immunoprecipitation (1-2 µg/sample)
      Paraffin Sections (1-10 µg/ml, neuraminidase pre-treatment required)
      DescriptionPurified rabbit polyclonal antibody. Recognizes parathyroid hormone-like protein (PTHLP).
      BackgroundParathyroid Hormone-Like Protein (PTHLP; also called Parathyroid Hormone-related Protein or PTHrP) is a polypeptide factor implicated in a severe neoplastic syndrome, Humoral Hypercalcemia of Malignancy, that is most commonly associated with renal cell and squamous cell carcinomas. It has been purified from tumors of patients with this syndrome and also from the conditioned medium of human tumor cell lines. Oligonucleotide probes, based upon the amino-terminal sequence of PTHLP, have been used to clone several cDNAs corresponding to alternatively spliced mRNAs that are both encoded by a single gene. Homogeneous recombinant PTHLP (141 amino acids) as well as synthetic peptides corresponding to the amino-terminal region of the protein have in vitro and in vivo biological activities as expected for a factor involved with calcium homeostasis. Immunohistochemical staining has shown PTHLP to be present in the keratinocyte layer of normal skin as well as in 34 out of 34 squamous or renal carcinomas but at a much lower percentage in adenocarcinomas.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide (AEIRATSEVSPNSKPSPNTK) corresponding to amino acids 34-53 of human PTHLP
      IsotypeIgG
      Specieshuman
      Positive controlAny renal carcinoma cell line or normal skin
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 0.2% gelatin.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsRecognizes human PTHLP, but the homology between the human and rat genes suggests that the antibody may also recognize PTHLP from other species. The antibody shows no cross reactivity with human parathyroid hormone. The immunogen, PTHLP (Peptide-1) Cat. Antibody should be titrated for optimal results in individual systems.
      Storage +2°C to +8°C
      Do Not Freeze Yes
      Toxicity Standard Handling
      ReferencesThorikay, M., et al. 1989. Endocrinology 124, 111.
      Danks, J.A., et al. 1988. J. Bone Min. Res. 3, S214.
      Mangin, M., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 597.
      Burtis, W.J., et al. 1987. J. Biol. Chem. 262, 7151.
      Moseley, J.M., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 5048.
      Strewler, G.J., et al. 1987. J. Clin. Invest. 80, 1803.
      Suva, L.J., et al. 1987. Science 237, 893.
      Godsall, J.W., et al. 1986. Recent Progress Hormone Res. 42, 705.