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MABN1623 Anti-FGF-9 Antibody, clone 3A10.1

Anti-FGF-9, clone 3A10.1 , Cat. No. MABN1623, is a highly specific mouse monoclonal antibody that targets FGF-9 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-FGF-9 Antibody, clone 3A10.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: FGF9, SYNS3 UniProt Number: P31371
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MABN1623
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1623
      DescriptionAnti-FGF-9 Antibody, clone 3A10.1
      Alternate Names
      • Fibroblast growth factor 9
      • FGF-9
      • GAF
      • Heparin-binding growth factor 9
      • Glia-activating factor
      • HBGF-9
      Background InformationFibroblast growth factor 9 (UniProt P31371; also known as FGF-9, GAF, Heparin-binding growth factor 9, Glia-activating factor, HBGF-9) is encoded by the FGF9 (also known as SYNS3) gene (Gene ID 2254) in human. Fibroblast growth factor 9 (FGF9) belongs to the FGF family of proteins that regulate a variety of cell functions, including proliferation, differentiation, survival, and motility, via FGF receptors (FGFRs). FGF-9 interacts with several FGFRs and binds preferentially to FGFR3. FGF-9 is highly expressed in cancer-associated fibroblasts (CAFs) in gastric cancer and may play a pivotal role in the interaction between cancer cells and their surrounding stromal cells. FGF-9 is shown to induce MMP-7 expression in AGS and MKN28 gastric cancer cells, promoting invasion and cellular anti-apoptotic activity through activation of the Erk and Akt signaling pathways. In human brain, FGF-9 is primarily expressed by neurons in the cortex, hippocampus, thalamus, cerebellum, and spinal cord, as well as by glia in the hindbrain and spinal cord. Upregulated FGF-9 expression is found in postmortem hippocampus tissues from major depressive disorder (MDD) patients, while FGF-2 is downregulated in the depressed brain. Likewise, chronic intracerebroventricular administration of FGF-9 increased both anxiety- and depression-like behaviors in rats, while FGF-9 knockdown in the dentate gyrus of the hippocampus ameliorated anxiety-like behavior. Human FGF-9 is produced with a propeptide (a.a. 1-3), which is cleaved off posttranslationally to yield the mature protein.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-FGF-9, clone 3A10.1 , Cat. No. MABN1623, is a highly specific mouse monoclonal antibody that targets FGF-9 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected FGF-9 in human cerebellum, cerebral cortex, and pancreas tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence within the C-terminal half of human FGF-9.
      Clone3A10.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 3A10.1 targets an internal sequence conserved among bovine, human, mouse, and rat species.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Bovine, Mouse, Porcine, Rat based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FGF9
      • SYNS3
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~23 kDa (non-glycosylated recombinant mature hFGF-9) observed. 23.14/23.44 kDa (human mature/pro-form), 23.08/23.38 kDa (bovine mature/pro-form), 23.11/23.41 kDa (mouse & rat mature/pro-form), 23.16/23.46 kDa (porcine mature/pro-form) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting of recombinant human FGF-9.

      Western Blotting Analysis: 2 µg/mL of this antibody detected 50 ng of E. coli expressed full-length recombinant human FGF-9.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1623 04054839069154