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MABN1595 Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1

This Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of SHTR2A.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: HTR2A, HTR2 UniProt Number: P28223
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MABN1595
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1595
      DescriptionAnti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1
      Alternate Names
      • 5-hydroxytryptamine receptor 2A
      • 5-HT-2
      • 5-HT-2A
      • 5-HT2A
      • Serotonin receptor 2A
      Background Information5-hydroxytryptamine receptor 2A (UniProt P28223; also known as 5-HT-2, 5-HT-2A, 5-HT2A, Serotonin receptor 2A) is encoded by the HTR2A (also known as HTR2) gene (Gene ID 3356) in human. Hydroxytryptamine (5-HT) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT2A receptor, which couples to Gq/11 to increase intracellular calcium, is widely expressed at central and peripheral sites of 5-HT action and contributes to many of the physiological effects of 5-HT. The hallucinogenic activity of LSD is mediated in part by its action as a partial to full agonist of 5-HT2A receptor, and the activity of atypical antipsychotics such as clozapine appears to be mediated in part by antagonism against 5-HT2A receptor. Human 5-HT2A receptor contains four extracellular domains (a.a. 1-75, 133-148, 216-233, 347-362), seven transmembrane segments (a.a. 76-99, 111-132, 149-171, 192-215, 234-254, 325-346, 363-384), and four cytoplasmic domains (a.a. 100-110, 172-191, 255-324, 385-471).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of SHTR2A.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: An 1:50 dilution from a representative lot detected 2A/HTR2A in human cerebral cortex, mouse cerebral cortex, and rat testis tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to the third cytoplasmic domain of human Serotonin receptor 2A/HTR2A.
      EpitopeThird cytoplasmic domain.
      Clone9B11.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms of human Serotonin receptor 2A reported by UniProt (P28223).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HTR2A
      • HTR2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~52 kDa observed. 52.60 kDa (isoform 1) and 43.94 kDa (isoform 2) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human cerebral cortex tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected 2A/HTR2A in 10 µg of human cerebral cortex tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1595 04055977331196

      Documentation

      Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1 Certificates of Analysis

      TitleLot Number
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 - 3198444 3198444
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 - 3429035 3429035
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 - 3746385 3746385
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 - 3942211 3942211
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 - 3979380 3979380
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 - 4113029 4113029
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 -Q2652391 Q2652391
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 Monoclonal Antibody 2975210
      Anti-Serotonin receptor 2A/HTR2A, clone 9B11.1 Monoclonal Antibody 3116259