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MABN1586 Anti-SCN2A Antibody, clone 5H10.2

This Anti-SCN2A Antibody, clone 5H10.2 is validated for use in Western Blotting for the detection of SCN2A.

Anti-SCN2A Antibody, clone 5H10.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SCN2A, EIEE11, BFIS3, NAC2, SCN2A1, SCN2A2 UniProt Number: Q99250
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MABN1586
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1586
      DescriptionAnti-SCN2A Antibody, clone 5H10.2
      Alternate Names
      • Sodium channel protein type 2 subunit alpha
      • HBSC II
      • Sodium channel protein brain II subunit alpha
      • Sodium channel protein type II subunit alpha
      • Voltage-gated sodium channel subunit alpha Nav1.2
      Background InformationSodium channel protein type 2 subunit alpha (UniProt Q99250; also known as HBSC II, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.2) is encoded by the SCN2A (also known as EIEE11, BFIS3, NAC2, SCN2A1, SCN2A2) gene (Gene ID 6326) in human. Sodium channels are integral plasma membrane proteins that conduct Na+ transport across the plasma membrane. They are classified as either voltage-gated or ligand-gated based on the nature of the triggering mechanism for channel activation. Voltage-gated sodium channels (VGSCs) are also called voltage-sensitive, voltage-dependent, or Nav channels. VGSCs normally consist of an alpha subunit that forms the ion-conducting pore and one to two beta subunits that have several functions including channel gating modulation, although the expression of the alpha subunit alone is sufficient to produce a functional channel. There exist nine known alpha subunits (Nav1.1 through Nav1.5 encoded by SCN1A through SCN5A and Nav1.6 through Nav1.9 encoded by SCN8A through SCN11A) and four beta subunits (Navbeta1 through Navbeta4 encoded by SCN1B through SCN4B). Beta 1 and beta 3 interact with the alpha subunit non-covalently, whereas beta 2 and beta 4 associate with alpha via disulfide bond. Nav1.2 is a multi-pass membrane protein with 24 membrane regions, having both its N- and C-terminal ends at the cytoplasmic side (a.a. 1-124 & 1777-2005).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-SCN2A Antibody, clone 5H10.2 is validated for use in Western Blotting for the detection of SCN2A.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant human SCN2A C-terminal cytoplasmic domain fragment.
      EpitopeC-terminal cytoplasmic domain.
      Clone5H10.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 5H10.2 targets an epitope in the C-terminal cytoplasmic domain.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SCN2A
      • EIEE11
      • BFIS3
      • NAC2
      • SCN2A1
      • SCN2A2
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~227-275 kDa observed. 228.0 kDa calculated. The braod banding pattern observed is consistent with the detection of differentially glycosylated and phosphorylated Nav1.2 protein. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human cortex tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected SCN2A in 10 µg of human cortex tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1586 04055977355444

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies