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MABN1539 Anti-Serotonin Receptor 1B Antibody, clone 1C2.1

Anti-Serotonin Receptor 1B, clone 1C2.1 Antibody, Cat. No. MABN1539, is a highly specific mouse monoclonal antibody that targets serotonin receptor 1B and has been tested in Immunohistochemistry (Paraffin), and Western Blotting.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: HTR1B, HTR1DB UniProt Number: P28222
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MABN1539
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RIH(P), WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1539
      DescriptionAnti-Serotonin Receptor 1B Antibody, clone 1C2.1
      Alternate Names
      • 5-hydroxytryptamine receptor 1B
      • 5-HT-1B
      • 5-HT-1D-beta
      • 5-HT1B
      • S12
      • Serotonin 1D beta receptor
      • Serotonin receptor 1B
      Background Information5-hydroxytryptamine receptor 1B (UniProt P28222; also known as 5-HT-1B, 5-HT-1D-beta, 5-HT1B, S12, Serotonin 1D beta receptor, Serotonin receptor 1B) is encoded by the HTR1B (also known as HTR1DB) gene (Gene ID 3351) in human. The 5-HT receptors are grouped according to their antagonist susceptibilities and their affinities for 5-HT. The 5-HT1 receptors are a subfamily of 5-HT receptors that were originally classified according to their inhibition of adenylyl cyclase, degree of sequence similarity and their overlapping pharmacological specificities. The subfamily has five different receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F that can couple to Gi/Go and mediate inhibitory neurotransmission. 5HT-1B receptor belong to the family of G-protein coupled receptors that are distributed in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. 5-HT-1B also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide. Ligand binding causes a conformation change in the receptor that triggers signaling via G-proteins, which modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling via 5-HT-1B inhibits adenylate cyclase activity. 5-HT1B receptor is known to be involved in thermoregulation, respiration, appetite control, sexual behavior, and aggression.
      5-HT-1B receptor are therapeutic targets for antimigraine drugs and for treatment of bipolar disorders, autism, and anti-aggressive agents.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Serotonin Receptor 1B, clone 1C2.1 Antibody, Cat. No. MABN1539, is a highly specific mouse monoclonal antibody that targets serotonin receptor 1B and has been tested in Immunohistochemistry (Paraffin), and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected serotonin receptor 1B in human (cerebellum and cerebral cortex) and rat (cerebral cortex and medulla) brain tissue sections.

      Western Blotting Analysis: 1 µg/mL from a representative lot detected serotonin receptor 1B in 10 µg of mouse brain tissue lysate.
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to the thrid cytoplasmic domain of human serotonin receptor 1B.
      Clone1C2.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 1C2.1 targets an epitope within the third cytoplasmic domain of human, mouse, and rat serotonin receptor 1B.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HTR1B
      • HTR1DB
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~43 kDa observed. 43.57/43.08/43.16 kDa (human/mouse/rat) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected serotonin receptor 1B in 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1539 04054839132964