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MABN128 Anti-PITX3 Antibody, clone 12G4.1

Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.

Anti-PITX3 Antibody, clone 12G4.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: PITX3, PTX3, ASMD, CTPP4, CTRCT11 UniProt Number: O75364
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MABN128
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN128
      DescriptionAnti-PITX3 Antibody, clone 12G4.1
      Alternate Names
      • Pituitary homeobox 3
      • Homeobox protein PITX3
      • Paired-like homeodomain transcription factor 3
      Background InformationPituitary homeobox 3 (UniProt O75364; also known as Homeobox protein PITX3, Paired-like homeodomain transcription factor 3) is encoded by the PITX3 (also known as ASMD, CTPP4, CTRCT11, PTX3) gene (Gene ID 5309) in human. PITX3 is a bicoid-related homeodomain transcription factor critical for the development of the ocular lens, mesencephalic dopaminergic neurons and skeletal muscle. PITX3 exerts its developmental impact on dopaminergic neurons by directly regulating the expression of a cascade of downstream genes, including TH, VMAT2, DAT, BDNF, and GDNF. PITX3 and the related PITX2 are both key regulators of intracellular redox state and play an important role in preventing DNA damage during fetal myogenesis. Human PITX3 gene mutations are linked to cataracts and anterior segment abnormalities and PITX3 polymorphisms are associated with Parkinson's disease. In aphakia (ak) mice, deletions in the Pitx3 promoter region cause abnormal lens development.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence within the N-terminal region of human PITX3.
      EpitopeN-terminal region.
      Clone12G4.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PITX3
      • PTX3
      • ASMD
      • CTPP4
      • CTRCT11
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~32 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human retinoblastoma Y79 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected PITX3 in 10 µg of human retinoblastoma Y79 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN128 04055977329452