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MABE628 Anti-CHUK, clone 3G12H9 Antibody

Anti-CHUK, clone 3G12H9 Antibody is an antibody against CHUK for use in Western Blotting, Immunocytochemistry.

Anti-CHUK, clone 3G12H9 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: CHUK, IKKA, TCF16 UniProt Number: O15111
MABE628
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABE628
      Replaces04-365
      DescriptionAnti-CHUK, clone 3G12H9 Antibody
      Alternate Names
      • Inhibitor of nuclear factor kappa-B kinase subunit alpha
      • I-kappa-B kinase alpha
      • IKK-A
      • IKK-alpha
      • IkBKA
      • IkappaB kinase
      • CHUK
      Background InformationInhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK), also known as, IKK-alpha (I-Kappa-B kinase-alpha), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. CHUK plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. Mutation in CHUK has been associated with Cocoon syndrome.
      References
      Product Information
      FormatAscites
      PresentationMouse monoclonal IgG1 ascitic fluid containing 0.03% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-CHUK, clone 3G12H9 Antibody is an antibody against CHUK for use in Western Blotting, Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis (ICC): A 1:200-1,000 dilution from a representative lot detected CHUK in NIH/3T3 cells.
      Biological Information
      ImmunogenPurified recombinant fragment of human CHUK expressed in E. Coli.
      Clone3G12H9
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • CHUK
      • IKKA
      • TCF16
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~75 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Raji, Jurkat, THP-1 and K562 cell lysates.

      Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected CHUK in Raji, Jurkat, THP-1 and K562 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABE628 04055977171723

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies