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MAB5346 Anti-RAR alpha Antibody, clone 76

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MAB5346
50 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB5346
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-RAR alpha Antibody, clone 76
      Alternate Names
      • RARalpha
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA, 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationAnti-RAR alpha Antibody, clone 763 is a Mouse Monoclonal Antibody for detection of Retinoic Acid Receptor also known as RAR alpha & has been validated in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blotting

      Immunohistochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPeptide from the N-terminus of human Retinoic Acid Receptor, alpha isotype.
      Clone763
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with Retinoic Acid Receptor, alpha isotype. By Western blot MAB5346 recognizes a ~48 kDa band in rat brain hippocampal homogenate.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RARA
      • RAR-alpha
      • NR1B1
      • RAR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10276 # This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.
      SIZE: 462 amino acids; 50771 Da
      SUBUNIT: Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NOCA7 in a ligand- inducible manner.
      SUBCELLULAR LOCATION: Nucleus.
      DOMAIN: SwissProt: P10276 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
      PTM: Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity).
      DISEASE:SwissProt: P10276 # Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM.
      SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MAB5346 04053252727498