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MAB3773 Anti-Annexin I Antibody, clone 6E4/3

Anti-Annexin I Antibody, clone 6E4/3 detects level of Annexin I & has been published & validated for use in ELISA, IF & WB.

Anti-Annexin I Antibody, clone 6E4/3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ANXA1, LPC1, Annexin-1, Chromobindin-9, ANX1, p35 UniProt Number: P04083
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MAB3773
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, IF, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB3773
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Annexin I Antibody, clone 6E4/3
      Alternate Names
      • Lipocortin I
      • Calpactin II
      • Chromobindin 9
      • Phospholipase A2 Inhibitory Protein
      Background InformationAnnexin I belongs to a family of Ca2+ dependent phospholipid binding proteins. It has been implicated in the regulation of phagocytosis, cell signaling and cell proliferation.
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-Annexin I Antibody, clone 6E4/3 detects level of Annexin I & has been published & validated for use in ELISA, IF & WB.
      Key Applications
      • ELISA
      • Immunofluorescence
      • Western Blotting
      Application NotesWestern blot

      Immunofluorescence

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenWhole native annexin proteins contained in a mixture of membrane proteins from human bone tissue
      Clone6E4/3
      HostMouse
      SpecificityRecognizes human Annexin I
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAnnexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
      Gene Symbol
      • ANXA1
      • LPC1
      • Annexin-1
      • Chromobindin-9
      • ANX1
      • p35
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04083 # Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
      SIZE: 346 amino acids; 38714 Da
      SUBUNIT: Homodimer in placenta (20%); linked by transglutamylation.
      SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity).
      DOMAIN: SwissProt: P04083 A pair of annexin repeats may form one binding site for calcium and phospholipid.
      PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.SIMILARITY: Belongs to the annexin family. & Contains 4 annexin repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB3773 04053252663307

      Documentation

      Anti-Annexin I Antibody, clone 6E4/3 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Annexin I Antibody, clone 6E4/3 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY 3315987
      MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2136613 2136613
      MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2141812 2141812
      MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2143459 2143459
      MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2148887 2148887
      MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2370677 2370677
      MOUSE ANTI-ANNEXIN I -2832231 2832231
      MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY 2989479

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies