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GF324 IL-1 Receptor Antagonist,
Human Recombinant Animal Free

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P18510
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GF324
100µg  
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      Overview

      Replacement Information

      Key Spec Table

      SourcePurity
      Protein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.      		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      Description
      Catalogue NumberGF324
      DescriptionIL-1 Receptor Antagonist,
      Human Recombinant Animal Free
      Alternate Names
      • IL-1
      • IL1RN
      Background InformationInterleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.
      References
      Product Information
      PresentationProduct is presented in 20 mM Tris, pH 8.0 and is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      Biological Information
      PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      SourceProtein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe ED50 was Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
      Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
      Packaging Information
      Material Size100µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GF324 04053252979644

      Documentation

      IL-1 Receptor Antagonist,
      Human Recombinant Animal Free SDS

      Title

      Safety Data Sheet (SDS) 

      IL-1 Receptor Antagonist,
      Human Recombinant Animal Free Certificates of Analysis

      TitleLot Number
      IL-1 Receptor Antagonist, Human Recombinant Animal Free - Q2441382 Q2441382
      IL-1 Receptor Antagonist, Human Recombinant Animal Free - 2561741 2561741
      IL-1 Receptor Antagonist, Human Recombinant Animal Free - 3207095 3207095
      IL-1 Receptor Antagonist, Human Recombinant Animal Free - 3574344 3574344
      IL-1 Receptor Antagonist, Human Recombinant Animal Free - 3782201 3782201
      IL-1 Receptor Antagonist, Human Recombinant Animal Free - 3863358 3863358
      IL-1 Receptor Antagonist, Human Recombinant Animal Free - 4049857 4049857
      IL-1 Receptor Antagonist, Human Recombinant Animal Free Recombinant Protein 3086147

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