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ABN1389 Anti-MARCO

Anti-MARCO, Cat. No. ABN1389, is a highly specific rabbit polyclonal antibody that targets Macrophage receptor MARCO and has been tested in Western Blotting.

Anti-MARCO MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: MARCO, SCARA2 UniProt Number: Q9UEW3
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ABN1389
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN1389
      DescriptionAnti-MARCO
      Alternate Names
      • Macrophage receptor with collagenous structure
      • Scavenger receptor class A member 2
      Background InformationMacrophage receptor MARCO (UniProt: Q9UEW3; also known as macrophage receptor with collagenous structure; Scavenger receptor class A member 2) is encoded by the MARCO (also known as SCARA2) gene (Gene ID: 8685) in human. MARCO is strongly expressed in macrophages of several tissues in humans with sepsis. It is a scavenger receptor that is readily upregulated following bacterial infection. Hence, it forms a back-up system through which the organism can quickly arm more cells with highly efficient phagocytosing receptors. MARCO is a single-pass type II membrane protein that binds both Gram-positive and Gram-negative bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. The bacteria-binding region is localized immediately proximal to the cysteine-rich region of domain V. Human and mouse MARCO exhibit about 68% sequence identity. However, the human MARCO subunit chain differs from the mouse chain in that it does not have any cysteine residues outside the cysteine-rich domain V, whereas the mouse chain has one cysteine residue within the intracellular domain I and two in the extracellular spacer domain III. (Ref.: Elomaa, O., et al. (1998). J. Biol. Chem. 273(8): 4350-4538).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-MARCO, Cat. No. ABN1389, is a highly specific rabbit polyclonal antibody that targets Macrophage receptor MARCO and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected MARCO in 10 µg of A549 cell lysate.
      Biological Information
      ImmunogenKLH-cojugated peptide corresponding to 12 amino acids from the C-terminal region of human MARCO.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody detects macrophage receptor MARCO in RAW264.7 cells.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MARCO
      • SCARA2
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~60 kDa observed; 52.65 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in RAW264.7 cells.

      Western Blotting Analysis (WB): A 1:5000 Dilution of this antibody detected Macrophage receptor MARCO in 10 µg RAW264.7 cells .
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN1389 04054839153327