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AB2285 Anti-Glutamate Receptor Delta 1/2 Antibody

Anti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB.

Anti-Glutamate Receptor Delta 1/2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GRID1, KIAA1220 , OTTHUMP00000059648 UniProt Number: Q9ULK0
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AB2285
100 µg   
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Pm, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2285
      DescriptionAnti-Glutamate Receptor Delta 1/2 Antibody
      Alternate Names
      • GluR delta-1
      • glutamate receptor, ionotropic, delta 1
      Background InformationThe majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels. Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989). These receptors have been implicated in a number of physiological and pathological processes. During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993). In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors. Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990). Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Rat cerebellum tissue lysate and human cerebellum tissue lysate.
      PresentationPurified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting:
      Human Cerebellum Lysate.
      Biological Information
      ImmunogenSynthetic linear peptide to the C-Terminus, conjugated to BSA.
      EpitopeC-Terminus, Cytoplasmic
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. # AB2285 reacts with the C-Terminus of Glutamate Receptor Delta 1/2.
      Species Reactivity
      • Human
      • Mouse
      • Primate
      • Rat
      Species Reactivity NoteProven to react with Rat and Human. Reacts weakly with mouse. May react with Primate based on sequence homology. Reactivity with other species has not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.
      Gene Symbol
      • GRID1
      • KIAA1220
      • OTTHUMP00000059648
      Purification MethodAntigen Affinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein by similarity. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein by similarity.

      SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) family.

      Molecular Weight~114 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blotting: 1:5,000 dilution from a previous lot detected Glutamate Receptor Delta 1/2 on 10 µg of rat or human cerebellum lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2285 04053252404320

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-Glutamate Receptor Delta 1/2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Glutamate Receptor Delta 1/2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Glutamate Receptor Delta 1/2 - 2443476 2443476
      Anti-Glutamate Receptor Delta 1/2 - 2002203 2002203
      Anti-Glutamate Receptor Delta 1/2 - 2377653 2377653
      Anti-Glutamate Receptor Delta 1/2 - 3275071 3275071
      Anti-Glutamate Receptor Delta 1/2 - 3683195 3683195
      Anti-Glutamate Receptor Delta 1/2 - NG1594516 NG1594516
      Anti-Glutamate Receptor Delta 1/2 - NG1817545 NG1817545
      Anti-Glutamate Receptor Delta 1/2 -2572478 2572478
      Anti-Glutamate Receptor Delta 1/2 -2780984 2780984
      Anti-Glutamate Receptor Delta 1/2 -2891864 2891864

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer