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852064 Fmoc-(FmocHmb)Gly-OH

Fmoc-(FmocHmb)Gly-OH Novabiochem®. CAS 148515-84-8, molar mass 655.71 g/mol.

Fmoc-(FmocHmb)Gly-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 148515-84-8 Molar Mass: 655.71 g/mol Hill Formula: C₄₀H₃₃NO₈
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852064
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
148515-84-8C₄₀H₃₃NO₈655.71 g/mol
Description
Catalogue Number852064
Replaces04-12-1135
Brand Family Novabiochem®
Alternate Names
  • N-α-Fmoc-N-α-(2-Fmoc-oxy-4-methoxybenzyl)-glycine
Background InformationHmb protection of amide bonds has been shown to inhibit aggregation of 'difficult' peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxyl group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].

The product number for this product was previously 04-12-1135.

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References
Product Information
CAS number148515-84-8
Hill FormulaC₄₀H₃₃NO₈
Molar Mass655.71 g/mol
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationFmoc-(FmocHmb)Gly-OH Novabiochem®. CAS 148515-84-8, molar mass 655.71 g/mol.
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 2 obviously hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Colour (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Purity (TLC(157A))≥ 98 %
Purity (TLC(157B))≥ 98 %
Assay (HPLC, area%)≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF)clearly soluble
Assay (acidimetric)≥ 95.0 %
Water (K. F.)≤ 1.00 %
For TLC-Systems see our General Catalog

Documentation

Fmoc-(FmocHmb)Gly-OH SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] T. Johnson, et al. (1993) J. Chem. Soc., Chem. Commun., 369.
  • [2] C. Hyde, et al. (1994) Int. J. Peptide Protein Res., 43, 431.
  • [3] L. C. Packman, et al. (1994) Pept. Res., 7, 125.
  • [4] T. Johnson, et al. (1994) Tetrahedron Lett., 35, 463.
  • [5] R. G. Simmonds (1996) Int. J. Peptide Protein Res., 47, 36.
  • [6] T. Johnson, et al. (1995) Lett. Pept. Sci., 1, 11.
  • [7] M. Quibell, et al. (1995) J. Am. Chem. Soc., 117, 11656.
  • [8] M. Quibell, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 1227.
  • [9] M. Quibell, et al. (1994) Tetrahedron Lett., 35, 2237.
  • [10] M. Quibell, et al. (1994) J. Org. Chem., 59, 1745.
  • [11] M. Quibell, et al. (1995) J. Chem. Soc., Perkin Trans. 1, 2019.
  • [12] M. Quibell, et al. (1994) J. Chem. Soc., Chem. Commun., 2343.
  • [13] L. C. Packman (1995) Tetrahedron Lett., 36, 7523.
  • [14] J. Offer, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 175.
  • [15] W. R. Sampson, et al. (1999) J. Peptide Sci., 5, 403.