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688225 Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem

Fluorogenic caspase-1 substrate.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-YVAD-AFC

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688225
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      Description
      OverviewFluorogenic caspase-1 substrate. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
      Catalogue Number688225
      Brand Family Calbiochem®
      SynonymsZ-YVAD-AFC
      References
      ReferencesJones, R.A., et al. 1998. Hepatology 27, 1632.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Walker, N.P., et al. 1994. Cell 78, 343.
      Thornberry, N.A., et al. 1992. Nature 356, 768.
      Product Information
      CAS number219137-85-6
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₃₃H₃₆F₃N₅O₁₀
      Chemical formulaC₃₃H₃₆F₃N₅O₁₀
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorogenic caspase-1 substrate
      Purity98±1% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAc-Tyr-Val-Ala-Asp-AFC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      688225-5MG 04055977225488

      Documentation

      Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      688225

      References

      Reference overview
      Jones, R.A., et al. 1998. Hepatology 27, 1632.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Walker, N.P., et al. 1994. Cell 78, 343.
      Thornberry, N.A., et al. 1992. Nature 356, 768.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      SynonymsZ-YVAD-AFC
      DescriptionFluorogenic ICE substrate. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. AFC (7-amino-4-trifluoromethylcoumarin) based fluorometric substrates are superior to AMC (7-amino-4-methylcoumarin) substrates because released AFC has a greater Stoke's shift than AMC. Excitation/emission maxima (nm) for AFC and AMC are 400/505 and 380/460, respectively.
      FormWhite to off-white solid
      CAS number219137-85-6
      Chemical formulaC₃₃H₃₆F₃N₅O₁₀
      Peptide SequenceAc-Tyr-Val-Ala-Asp-AFC
      Structure formulaStructure formula
      Purity98±1% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJones, R.A., et al. 1998. Hepatology 27, 1632.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Walker, N.P., et al. 1994. Cell 78, 343.
      Thornberry, N.A., et al. 1992. Nature 356, 768.