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681637 Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III

Primary Target: Wee1 and Chk1
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      1177150-89-8C₂₀H₁₂N₂O₃ • H₂O
      Description
      Overview

      This product has been discontinued.



      A pyrrolocarbazole compound that acts as a potent and ATP-competitive inhibitor of checkpoint kinases Wee1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). Inhibits PKC, Cdk4, or other CDKs only at much higher concentrations (IC50 = 3.4 µM, 3.75 µM, and >5 µM, respectively) and exhibits little effect against FGFR, PDGFR, or c-Src (IC50 >50 µM).
      Catalogue Number681637
      Brand Family Calbiochem®
      Synonyms4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III
      References
      ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Squire, C.J., et al. 2005. Structure 13, 541.
      Product Information
      CAS number1177150-89-8
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₂₀H₁₂N₂O₃ • H₂O
      Chemical formulaC₂₀H₁₂N₂O₃ • H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetWee1 and Chk1
      Primary Target IC<sub>50</sub>97 nM and 47 nM against Wee1 and Chk1, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      681637 0