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662107 UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem

The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Nitro-5-tosylfuran, Ubc13 Inhibitor, NSC697923, UBE2N Inhibitor, Ubiquitin-Conjugating Enzyme E2 N Inhibitor

Primary Target: Ubc13
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662107
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Overview

Key Spec Table

CAS #Empirical Formula
343351-67-8C₁₁H₉NO₅S

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662107-25MG
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      Description
      OverviewA cell-permeable nitrofuran compound that selectively inhibits the E2 Ubiquitin-conjugating enzyme Ubc13- (Cat. No. 438075), but not UbcH5c-, catalyzed K63-linked polyUb chain formation by preventing Ubc13-Ub thioester bond formation. Effectively inhibits Ubc13-Uev1A (UBE2V1) E2 complex-mediated NF-κB activation, Ubc13-Mms2 (UBEV2) E2 complex-mediated DNA DSB (double-strand break) repair activation, as well as Ubc13-dependent p53 nuclear export in cultures (1 to 2 µM). The combined NF-κB inhibition and p53 activation via Ubc13 inhibition is shown to be particularly effective against the proliferation of ABC (Activated B-cell-like) and GCB (Germinal center B-cell-like) DLBCL (Diffuse Large B-Cell Lymphoma) cell lines and primary DLBCL cultures via apoptosis induction (1 to 2 µM).
      Catalogue Number662107
      Brand Family Calbiochem®
      Synonyms2-Nitro-5-tosylfuran, Ubc13 Inhibitor, NSC697923, UBE2N Inhibitor, Ubiquitin-Conjugating Enzyme E2 N Inhibitor
      References
      ReferencesPulvino, M., et al. 2012. Blood 1668.
      Product Information
      CAS number343351-67-8
      FormOff-white powder
      Hill FormulaC₁₁H₉NO₅S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetUbc13
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      662107-25MG 04055977261202