662107 Sigma-AldrichUbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem
The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The UbcH13 Inhibitor, NSC697923 controls the biological activity of UbcH13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: NSC697923, UBE2N Inhibitor, Ubiquitin-Conjugating Enzyme E2 N Inhibitor, 2-Nitro-5-tosylfuran, Ubc13 Inhibitor
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 343351-67-8 | C₁₁H₉NO₅S |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 662107-25MG |
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Glass bottle | 25 mg |
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| Description | |
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| Overview | A cell-permeable nitrofuran compound that selectively inhibits the E2 Ubiquitin-conjugating enzyme Ubc13- (Cat. No. 438075), but not UbcH5c-, catalyzed K63-linked polyUb chain formation by preventing Ubc13-Ub thioester bond formation. Effectively inhibits Ubc13-Uev1A (UBE2V1) E2 complex-mediated NF-κB activation, Ubc13-Mms2 (UBEV2) E2 complex-mediated DNA DSB (double-strand break) repair activation, as well as Ubc13-dependent p53 nuclear export in cultures (1 to 2 µM). The combined NF-κB inhibition and p53 activation via Ubc13 inhibition is shown to be particularly effective against the proliferation of ABC (Activated B-cell-like) and GCB (Germinal center B-cell-like) DLBCL (Diffuse Large B-Cell Lymphoma) cell lines and primary DLBCL cultures via apoptosis induction (1 to 2 µM). |
| Catalogue Number | 662107 |
| Brand Family | Calbiochem® |
| Synonyms | NSC697923, UBE2N Inhibitor, Ubiquitin-Conjugating Enzyme E2 N Inhibitor, 2-Nitro-5-tosylfuran, Ubc13 Inhibitor |
| References | |
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| References | Pulvino, M., et al. 2012. Blood |
| Product Information | |
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| CAS number | 343351-67-8 |
| Form | Off-white powder |
| Hill Formula | C₁₁H₉NO₅S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Ubc13 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 662107-25MG | 04055977261202 |
Documentation
UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem SDS
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UbcH13 Inhibitor, NSC697923 - CAS 343351-67-8 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 662107 |
References
| Reference overview |
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| Pulvino, M., et al. 2012. Blood |
| Data Sheet | ||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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