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658390 AG 9 - CAS 2826-26-8 - Calbiochem

AG 9 - CAS 2826-26-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [(4-Methoxybenzylidene)malononitrile, α-Cyano-(4-methoxy)cinnamonitrile], Tyrphostin A1

Primary Target: negative control for inhibition of EGFR
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      2826-26-8C₁₁H₈N₂O
      Description
      Overview

      This product has been discontinued.



      An inactive compound that can be used as a negative control for inhibition of EGFR (IC50 >1250 µM for EGFR kinase). Has been shown to inhibit IL-2 stimulated Tyk-2 phosphorylation in ConA-activated T cells.
      Catalogue Number658390
      Brand Family Calbiochem®
      Synonyms[(4-Methoxybenzylidene)malononitrile, α-Cyano-(4-methoxy)cinnamonitrile], Tyrphostin A1
      References
      ReferencesBright, J.J., et al. 1999. J. Immunol. 162, 6255.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Ruetten, H. and Thiemermann, C. 1997. Br. J. Pharmacol. 122, 59.
      Product Information
      CAS number2826-26-8
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₁H₈N₂O
      Chemical formulaC₁₁H₈N₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetnegative control for inhibition of EGFR
      Primary Target IC<sub>50</sub>>1250 µM for EGFR kinase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      658390 0

      Documentation

      AG 9 - CAS 2826-26-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AG 9 - CAS 2826-26-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      658390

      References

      Reference overview
      Bright, J.J., et al. 1999. J. Immunol. 162, 6255.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Ruetten, H. and Thiemermann, C. 1997. Br. J. Pharmacol. 122, 59.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2008 RFH
      Synonyms[(4-Methoxybenzylidene)malononitrile, α-Cyano-(4-methoxy)cinnamonitrile], Tyrphostin A1
      DescriptionInactive inhibitor that can be used as a negative control for inhibition of EGFR (IC50 >1250 µM for EGFR kinase). Has been shown to inhibit IL-2 stimulated Tyk-2 phosphorylation in ConA-activated T cells.
      FormYellow solid
      CAS number2826-26-8
      Chemical formulaC₁₁H₈N₂O
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityAcetic acid, DMSO, or ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesBright, J.J., et al. 1999. J. Immunol. 162, 6255.
      Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Ruetten, H. and Thiemermann, C. 1997. Br. J. Pharmacol. 122, 59.