Millipore Sigma Vibrant Logo

654164 Tubulin Polymerization Inhibitor II

The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications.

Tubulin Polymerization Inhibitor II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one

Primary Target: Purified porcine brain tubulin
View Products on Sigmaaldrich.com
654164
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1151995-69-5C₁₉H₁₉NO₅

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
654164-5MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 5 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50 <10 nM for 46 lines among a 53 NCI panel tested).
      Catalogue Number654164
      Brand Family Calbiochem®
      Synonyms(E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
      References
      ReferencesPandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492.
      Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382.
      Product Information
      CAS number1151995-69-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₉NO₅
      Chemical formulaC₁₉H₁₉NO₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPurified porcine brain tubulin
      Primary Target IC<sub>50</sub>4.5 µM in inhibiting polymerization of purified porcine brain tubulin
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      654164-5MG 04055977184587

      Documentation

      Tubulin Polymerization Inhibitor II SDS

      Title

      Safety Data Sheet (SDS) 

      Tubulin Polymerization Inhibitor II Certificates of Analysis

      TitleLot Number
      654164

      References

      Reference overview
      Pandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492.
      Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms(E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
      DescriptionA cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50 <10 nM for 46 lines among a 53 NCI panel tested).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1151995-69-5
      Chemical formulaC₁₉H₁₉NO₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesPandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492.
      Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382.