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616394 TPEN - CAS 16858-02-9 - Calbiochem

TPEN - CAS 16858-02-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine

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616394
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
16858-02-9C₂₆H₂₈N₆

Pricing & Availability

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616394-100MG
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      		 Plastic ampoule 100 mg
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      Description
      OverviewLipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ levels in cells. Also useful in extracting Aβ amyloid deposits from Alzheimer’s disease brain tissue. Has extremely high affinity for heavy metals but low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2 (Cat. No. 551826).
      Catalogue Number616394
      Brand Family Calbiochem®
      SynonymsN,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine
      References
      ReferencesFonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
      Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
      Aballay, A., et al. 1995. Biochem. J. 312, 919.
      Jiang, S., et al. 1995. Lab. Invest. 73, 111.
      Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
      McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
      Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
      Baba, A., et al. 1991. Brain Res. 557, 103.
      Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
      Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
      Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
      Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.
      Product Information
      CAS number16858-02-9
      FormTan solid
      Hill FormulaC₂₆H₂₈N₆
      Chemical formulaC₂₆H₂₈N₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by titration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      616394-100MG 04055977185621

      Documentation

      TPEN - CAS 16858-02-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TPEN - CAS 16858-02-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      616394

      References

      Reference overview
      Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
      Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
      Aballay, A., et al. 1995. Biochem. J. 312, 919.
      Jiang, S., et al. 1995. Lab. Invest. 73, 111.
      Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
      McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
      Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
      Baba, A., et al. 1991. Brain Res. 557, 103.
      Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
      Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
      Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
      Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2010 RFH
      SynonymsN,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine
      DescriptionLipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ in cells. Has an extremely high affinity for heavy metals but a low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and causes apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2. Shown to be useful in extracting Aβ depostis from Alzheimer's disease brain tissue.
      FormTan solid
      CAS number16858-02-9
      Chemical formulaC₂₆H₂₈N₆
      Structure formulaStructure formula
      Purity≥97% by titration
      SolubilityDMSO, Ethanol (10 mg/ml), or PBS (25 µM in 100 mM PBS, pH 7.0)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
      Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
      Aballay, A., et al. 1995. Biochem. J. 312, 919.
      Jiang, S., et al. 1995. Lab. Invest. 73, 111.
      Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
      McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
      Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
      Baba, A., et al. 1991. Brain Res. 557, 103.
      Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
      Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
      Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
      Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.