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573106 STAT3 Inhibitor X, HJB - Calbiochem

The STAT3 Inhibitor X, HJB controls the biological activity of STAT3.

STAT3 Inhibitor X, HJB - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 17-Hydroxy-jolkinolide B, HJB

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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₀H₂₆O₅
      Description
      Overview

      This product has been discontinued.



      A diterpene diepoxide compound, which demonstrates high selectivity for the JAK/STAT3 signaling pathway and shows anti-tumor properties in certain human cancer cell lines at a concentration of ~12 µM. HJB suppresses IL-6-induced STAT-3 transcription activity (IC50= ˜ 3.34 µM) in HepG2 cells and inhibits IL-6-induced and constitutive STAT-3 tyrosine phosphorylation at a concentration of 10 µM in a select few human cancer cell lines. In HEK 293 culture, HJB hinders JAK kinase activity (IC50 <10 µM) and induces JAK dimerization via cross-linking at a concentration of 20 µM.
      Catalogue Number573106
      Brand Family Calbiochem®
      Synonyms17-Hydroxy-jolkinolide B, HJB
      References
      ReferencesWang, Y., et al. 2009, Canc. Res. 69, 7302.
      Product Information
      FormOff-white solid
      Hill FormulaC₂₀H₂₆O₅
      Chemical formulaC₂₀H₂₆O₅
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      573106 0

      Documentation

      STAT3 Inhibitor X, HJB - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      STAT3 Inhibitor X, HJB - Calbiochem Certificates of Analysis

      TitleLot Number
      573106

      References

      Reference overview
      Wang, Y., et al. 2009, Canc. Res. 69, 7302.

      Technical Info

      Title
      JAK/STAT Signaling Research Focus
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-September-2010 JSW
      Synonyms17-Hydroxy-jolkinolide B, HJB
      DescriptionA diterpene diepoxide compound, which demonstrates high selectivity for the JAK/STAT3 signaling pathway and shows anti-tumor properties in certain human cancer cell lines at a concentration of ~12 µM. HJB suppresses IL-6-induced STAT-3 transcription activity (IC50= ˜ 3.34 µM) in HepG2 cells and inhibits IL-6-induced and constitutive STAT-3 tyrosine phosphorylation at a concentration of 10 µM in a select few human cancer cell lines. In HEK 293 culture, HJB hinders JAK kinase activity (IC50 <10 µM) and induces JAK dimerization via cross-linking at a concentration of 20 µM.
      FormOff-white solid
      Chemical formulaC₂₀H₂₆O₅
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, Y., et al. 2009, Canc. Res. 69, 7302.